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West Bromwich Albion take on Burnley at The Hawthorns in Monday night action from the Premier League.
Marcelo Bielsa's Leeds United look to continue a fine start to the season as they welcome Nuno Espirito Santo's Wolves for Monday Night Football at Elland Road.
Norwich City take on Birmingham City at Carrow Road in the Sky Bet Championship.
Millwall host Luton Town at The Den in the Sky Bet Championship.
Manchester United travel to France to face PSG in the UEFA Champions League at Parc des Princes. Ole Gunnar Solskjaer's side picked won a thriller here 3-1 back in 2019.
Chelsea welcome Europa League holders Sevilla to Stamford Bridge for their UEFA Champions League tie. This will be the first ever European encounter between the two sides.
Sheffield Wednesday take on Brentford at Hillsborough Stadium in the Sky Bet Championship. The Owls came behind to beat the Bees 2-1 in this game last season.
Dutch champions Ajax face Liverpool in the UEFA Champions League at the Amsterdam Arena. The two sides meet for the first time since the 1966/67 European Cup.
Manchester City welcome Porto to the Etihad Stadium in Group C of the Champions League. City will be hoping for a repeat of last season's group stages in which they went unbeaten.
Arsenal kick-off their UEFA Europa League campaign with a trip to Austria to face Rapid Wien at Allianz Stadion.
Rangers travel to Stade Maurice Dufrasne to take on Standard Liege in Group D of the UEFA Europa League.
Tottenham welcome LASK to North London for their opening UEFA Europa League fixture of the season at the Tottenham Hotspur Stadium.
Celtic welcome AC Milan to Celtic Park in the opening group game of the UEFA Europa League.
Leicester City welcome Ukrainian side Zorya Luhansk to the King Power Stadium for their opening UEFA Europa League match.
A Friday night derby clash from the Sky Bet Championship as Nottingham Forest welcome local rivals Derby County to the City Ground. Forest won 1-0 in this fixture last season.
Two sides relegated from last season's Premier League clash at Vicarage Road as Watford welcome Bournemouth for the early kick-off from the Sky Bet Championship.
Manchester City travel to the London Stadium to take on West Ham in their latest Premier League test.
Ole Gunnar Solskjaer's Manchester United welcome Frank Lampard's Chelsea to Old Trafford in Saturday evening action from the Premier League.
Liverpool welcome Sheffield United to Anfield in Saturday evening action from the Premier League.